Data Sheet

MSDS

Edicotinib [CAS 1142363-52-7]

CAS No:	1142363-52-7
Applications:	COVID-19-immunoregulation
MW:	461.60
Formula:	C₂₇H₃₅N₅O₂
SMILES:	O=C(C1=NC=C(C#N)N1)NC2=C(C3=CCC(C)(C)CC3)N=C(C(CC(C)(C)O4)CC4(C)C)C=C2
Purity:	98.78
Description:	Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active�colony-stimulating factor-1 receptor (CSF-1R)�inhibitor with an IC50 of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively[1]. Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration�in mice. Edicotinib has the potential for Alzheimer�s disease and rheumatoid arthritis research[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only