Description: | Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active�colony-stimulating factor-1 receptor (CSF-1R)�inhibitor with an IC50 of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively[1]. Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration�in mice. Edicotinib has the potential for Alzheimer�s disease and rheumatoid arthritis research[1][2]. |