Data Sheet

MSDS

AMN082 (free base) [CAS 83027-13-8]

CAS No:	83027-13-8
Applications:	Neuroscience-Neuromodulation
MW:	392.54
Formula:	C₂₈H₂₈N₂
SMILES:	C(NCCNC(C1=CC=CC=C1)C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
Purity:	99.07
Description:	AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTP?S binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only