Data Sheet

MSDS

Masitinib [CAS 790299-79-5]

CAS No:	790299-79-5
Applications:	Cancer-Kinase/protease
MW:	498.64
Formula:	C₂₈H₃₀N₆OS
SMILES:	O=C(NC1=CC=C(C(NC2=NC(C3=CC=CN=C3)=CS2)=C1)C)C4=CC=C(CN5CCN(CC5)C)C=C4
Purity:	99.98
Description:	Masitinib (AB1010) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit). It also inhibits PDGFR?/? (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, FGFR3 and FAK. Masitinib (AB1010) has anti-proliferative, pro-apoptotic activity and low toxicity[1][2][4].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only