Data Sheet

MSDS

Avapritinib [CAS 1703793-34-3]

CAS No:	1703793-34-3
Applications:	Cancer-Kinase/protease
MW:	498.56
Formula:	C₂₆H₂₇FN₁₀
SMILES:	CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC=N3)=C2)=C1
Purity:	99.94
Description:	Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only