Data Sheet

MSDS

JNJ-39758979 [CAS 1046447-90-8]

CAS No:	1046447-90-8
Applications:	Neuroscience-Neuromodulation
MW:	221.30
Formula:	C₁₁H₁₉N₅
SMILES:	NC1=NC(C(C)C)=CC(N2C[C@H](N)CC2)=N1
Purity:	98.0
Description:	JNJ-39758979 is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only