O-Desmethyl gefitinib-d8
Partner: MedChemexpress LLC
| Applications: | Cancer-Kinase/protease |
| MW: | 440.93 |
| Formula: | C21H14D8ClFN4O3 |
| SMILES: | OC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4C([2H])([2H])C([2H])([2H])OC([2H])([2H])C4([2H])[2H] |
| Purity: | 99.84 |
| Description: | O-Desmethyl gefitinib-d8 is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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