Data Sheet

MSDS

SKF-96365 (hydrochloride) [CAS 130495-35-1] (10mM in DMSO)

CAS No:	130495-35-1
Applications:	Cancer-Kinase/protease
MW:	402.91
Formula:	C₂₂H₂₇ClN₂O₃
SMILES:	COC1=CC=C(CCCOC(C2=CC=C(OC)C=C2)CN3C=CN=C3)C=C1.[H]Cl
Purity:	99.91
Description:	SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2+ entry (SOCE) inhibitor. SKF-96365 hydrochloride significantly inhibits hERG, hKCNQ1/hKCNE1, hKir2.1 and hKv4.3 current, and significantly prolongs the QTc interval in isolated guinea pig hearts. SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells[1][2].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only