| Applications: | CHiP, FC, IHC, IHC(p), EMSA |
| Isotype: | Mouse |
| Purification: | PBS, 0.1% BSA, 0.05% azide |
| Conjugation: | CF405S |
| Description: | Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors. Primary antibodies are available purified, or with a selection of fluorescent CF� Dyes and other labels. CF� Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF�405S and CF�405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors. |
| Further Information: | CHiP (published)|Flow, intracellular (published)|IHC (published)|IHC, FFPE (published)|EMSA (published) |
| Shipping Conditions: | Ship at ambient |
| Storage: | Store at 4 C |
| Usage: | Research Use Only |
