| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 23.5kDa (204aa);;18-28kDa (SDS-PAGE under reducing conditions);; |
| Purity: | > 90% by SDS - PAGE |
| Description: | TIMP4, as known as metalloproteinase inhibitor 4, is a family of secreted protein that regulates the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases. There are four known members of the family, TIMP1, 2, 3 and 4. TIMP4 is produced by a wide range of tissues, particularly brain, heart, ovary and skeletal muscle. Limited studies have shown that this protein has a tumor suppressive effect against Wilm s tumor, exhibits negative correlation with glioma malignancy and is found in breast carcinoma cells. Recombinant human TIMP4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: ADPCSCAPAH PQQHICHSAL VIRAKISSEK VVPASADPAD TEKMLRYEIK QIKMFKGFEK VKDVQYIYTP FDSSLCGVKL EANSQKQYLL TGQVLSDGKV FIHLCNYIEP WEDLSLVQRE SLNHHYHLNC GCQITTCYTV PCTISAPNEC LWTDWLLERK LYGYQAQHYV CMKHVDGTCS WYRGHLPLRK EFVDIVQPHH HHHH |
| Synonym: | Metalloproteinase inhibitor 4, TIMP4, TIMP-4, Metalloproteinase inhibitor 4, TIMP 4, TIMP metallopeptidase inhibitor 4, TIMP-4, Timp4, TIMP4_HUMAN, Tissue inhibitor of metalloproteinase 4, Tissue inhibitor of metalloproteinases 4 |
| Ascension Number: | Q99727 |
| NCBI EntrezGene: | NP_003247 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
