Applications: | SDS-PAGE, Denatured |
Species Reactivity: | Human |
MW: | 26.1kDa (218aa) |
Purity: | > 85% by SDS - PAGE |
Description: | AICDA, also known as AID, is involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. This protein is required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. It may also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Recombinant human AICDA protein, fused to His-tag at N-terminus, was expressed in E. coli. |
Further Information: | Sequence: MGSSHHHHHH SSGLVPRGSH MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR NKNGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT FVENHERTFK AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL |
Synonym: | Activation-induced cytidine deaminase, AID, ARP2, CDA2, HIGM2 |
Ascension Number: | Q9GZX7 |
NCBI EntrezGene: | NP_065712 |
Shipping Conditions: | Ship on cold packs |
Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
Usage: | Research use only |