| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 16.6kDa (152aa), confirmed by MALDI-TOF. |
| Purity: | > 95% by SDS - PAGE |
| Description: | CDK2AP1 is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. Also, interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes. Recombinant CDK2AP1 protein was expressed in E. coli and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSY KPNLAAHMPA AALNAAGSVH SPSTSMATSS QYRQLLSDYG PPSLGYTQGT GNSQVPQSKY AELLAIIEEL GKEIRPTYAG SKSAMERLKR GIIHARGLVR ECLAETERNA RS |
| Synonym: | Cyclin-dependent kinase 2 associated protein 1, CDKAP1, DOC1, CDKA1, Cyclin-dependent kinase 2 associated protein 1 CDK2 A1, CDK2 associated protein 1, CDK2AP1, Cyclin dependent kinase 2 associated protein 1 Deleted in oral cancer 1, DOC 1, DOC 1 related protein, DOC 1R, DOC1R, Putative oral cancer suppressor. |
| Ascension Number: | O14519 |
| NCBI EntrezGene: | NP_004633 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
