Ordering Details
Cat Number:	ATGP0412-50ug
Size:	50ug
Concentration:	0.5 mg/mL (determined by Bradford assay)
Price:	£267.00
Quantity:
Shipping:	£12.00

LIN-28A [42-209 a.a.], Recombinant Protein

Partner: NKMax Bio (ATGen)

Applications:	SDS-PAGE
Species Reactivity:	Human
MW:	21.1 kDa (191aa), confirmed by MALDI-TOF.
Purity:	> 85% by SDS - PAGE
Description:	Lin-28 acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. It is marker of undifferentiated human embryonic stem cells and has been used to enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts. It has also been shown to bind to the let-7 pre-miRNA and block production of the mature let-7 microRNA in mouse embryonic stem cells. Recombinant Lin28 protein was expressed in E. coli and purified by using conventional chromatography techniques.
Further Information:	Sequence: MGSSHHHHHH SSGLVPRGSH RSMGICKWFN VRMGFGFLSM TARAGVALDP PVDVFVHQSK LHMEGFRSLK EGEAVEFTFK KSAKGLESIR VTGPGGVFCI GSERRPKGKS MQKRRSKGDR CYNCGGLDHH AKECKLPPQP KKCHFCQSIS HMVASCPLKA QQGPSAQGKP TYFREEEEEI HSPTLLPEAQ N
Synonym:	Zinc finger CCHC domain-containing protein 1, CSDD1, FLJ12457, LIN-28, LIN28A, ZCCHC1, Zinc finger CCHC domain-containing protein 1 AL024421.Lin 28, Lin 28 homolog, Tex17, Lin28a, Lin 28 homolog (C, elegans), Lin 28 homolog A, RNA binding protein lin 28, Zinc finger CCHC domain containing protein 1.
Ascension Number:	Q9H9Z2
NCBI EntrezGene:	NP_078950
Shipping Conditions:	Ship on cold packs
Storage:	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Usage:	Research use only