| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 23.9 kDa (207aa), confirmed by MALDI-TOF. |
| Purity: | > 90% by SDS-PAGE |
| Description: | Cysteine dioxygenase (CDO1) is a mammalian non-heme iron enzyme that initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. This protein catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate) by incorporation of dioxygen. CDO1 is critical regulator of cellular cysteine concentrations and has an important role in maintaining the hepatic concentration of intracellular free cysteine within a proper narrow range. Recombinant CDO1 protein was expressed in E. coli and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMEQ TEVLKPRTLA DLIRILHQLF AGDEVNVEEV QAIMEAYESD PTEWAMYAKF DQYRYTRNLV DQGNGKFNLM ILCWGEGHGS SIHDHTNSHC FLKMLQGNLK ETLFAWPDKK SNEMVKKSER VLRENQCAYI NDSVGLHRVE NISHTEPAVS LHLYSPPFDT CHAFDQR |
| Synonym: | CDO1, CDO, CDO 1, CDO I, CDO-1, CDO-I, CDOI, cytosolic cysteine dioxygenase. |
| Ascension Number: | Q16878 |
| NCBI EntrezGene: | AAH_24241 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
