| Applications: | ELISA, WB, FACS, ICC/IF |
| Species Reactivity: | Human |
| Isotype: | Mouse IgG2a kappa |
| Immunogen: | Recombinant human GPI (1-558aa) purified from E. coli |
| Purification: | By protein-A affinity chromatography |
| Conjugation: | Unconjugated |
| Description: | Glucose-6-phosphate isomerase (GPI), also known as phosphoglucose isomerase (PGI) or phosphohexose isomerase (PHI), is an enzyme. In the cytoplasm, it functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate (G6P) and fructose-6-phosphate (F6P). Extracellularly, it functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. GPI is also referred to as autocrine motility factor (AMF) based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in GPI are the cause of nonspherocytic hemolytic anemia, and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. |
| Further Information: | The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. |
| Synonym: | Glucose-6-phosphate isomerase, GPI, AMF, GNPI, NLK, PGI, PHI, SA36, EC 5.3.1.9, Neuroleukin, Phosphoglucose isomerase, Phosphohexose isomerase, SA 36, Sperm antigen 36, G6PI, Glucose-6-phosphate isomerase |
| Ascension Number: | P06744 |
| NCBI EntrezGene: | NP_000166 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
