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Cat Number:ATGA0133-50ul
Size:50ul
Concentration:1mg/ml
Price:£118.00
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Shipping:£10.00

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Data Sheet
MSDS

 

NFATC1 [AT1C3], Mouse Monoclonal Antibody

Partner: ATGen

Applications:ELISA, WB, FACS, ICC/IF
Species Reactivity:Human
Isotype:Mouse IgG2a kappa
Immunogen:Recombinant human NFATc1 (428-716aa) purified from E. coli
Purification:By protein-G affinity chromatography
Conjugation:Unconjugated
Description:Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1) is a component of the nuclear factor of activated T cells DNA-binding transcription complex which consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. This protein plays a main role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription and functions as a major molecular target for the immunosuppressive drugs such as cyclosporine A. NFATc1 is expressed in most human primary lymphocytes and mature human T- and B-cell neoplasms.
Further Information:The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Synonym:nuclear factor of activated T-cells, cytosolic component 1 isoform A, NF-ATC, NFATc, NFAT2
Ascension Number:O95644
NCBI EntrezGene:NP_765978
Shipping Conditions:Ship on cold packs
Storage:Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Usage:Research use only

 

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Cell lysates of Ramos (20ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human NFATc1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Cell lysates of Ramos (20ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human NFATc1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.