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Cat Number:AP20781a-ev
Size:80uL
Price:£117.00
Quantity:
Shipping:£12.00

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Data Sheet
MSDS

 

FGFR4 [N-term] [RB50684], Rabbit Polyclonal Antibody

Partner: Abcepta, Inc.

Applications:WB
Species Reactivity:Human
Isotype:Rabbit Ig
Purification:Purified Rabbit Polyclonal Antibody
Description: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
Further Information:This FGFR4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 143-178 amino acids from the N-terminal region of human FGFR4.
Synonym:Fibroblast growth factor receptor 4, FGFR-4, CD334, FGFR4, JTK2, TKF
Ascension Number:P22455
NCBI EntrezGene:2264
Shipping Conditions:Ship on cold packs
Storage:Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles.
Usage:Research use only

 

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Western blot analysis of lysate from SW480 cell line, using FGFR4 Antibody (N-term)(Cat.  #AP20781a).  AP20781a was diluted at 1:1000.  A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.

Western blot analysis of lysate from SW480 cell line, using FGFR4 Antibody (N-term)(Cat. #AP20781a). AP20781a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.