| Applications: | IHC-P, WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | Genes encoding LIM domain-binding factors were initiallyisolated in a screen for proteins that physically interact with theLIM domains of nuclear proteins (summarized by Semina et al., 1998[PubMed 9799849]). These proteins, such as the one encoded by theLDB2 gene, are capable of binding to a variety of transcriptionfactors and are likely to function at enhancers to bring togetherdiverse transcription factors and form higher order activationcomplexes or to block formation of such complexes (Jurata and Gill,1997 [PubMed 9315627]). The family of genes encoding LIMdomain-binding factors includes 2 members isolated from the mouse,Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli(Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996[PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and theirhomologs cloned from the frog, chicken, and fly. The fact that LIMdomain-binding factors are likely to be involved in thecoordination of the transcriptional activity of many diversefactors might implicate them in human phenotypes characterized bymultiple affected sites. |
| Further Information: | This LDB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-342 amino acids from the C-terminal region of human LDB2. |
| Synonym: | LIM domain-binding protein 2, LDB-2, Carboxyl-terminal LIM domain-binding protein 1, CLIM-1, LIM domain-binding factor CLIM1, LDB2, CLIM1 |
| Ascension Number: | O43679 |
| NCBI EntrezGene: | 9079 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
