| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit IgG |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | Adducins are heteromeric proteins composed of differentsubunits referred to as adducin alpha, beta and gamma. The threesubunits are encoded by distinct genes and belong to a family ofmembrane skeletal proteins involved in the assembly ofspectrin-actin network in erythrocytes and at sites of cell-cellcontact in epithelial tissues. While adducins alpha and gamma areubiquitously expressed, the expression of adducin beta isrestricted to brain and hematopoietic tissues. Adducin, originallypurified from human erythrocytes, was found to be a heterodimer ofadducins alpha and beta. Polymorphisms resulting in amino acidsubstitutions in these two subunits have been associated with theregulation of blood pressure in an animal model of hypertension.Heterodimers consisting of alpha and gamma subunits have also beendescribed. Structurally, each subunit is comprised of two distinctdomains. The amino-terminal region is protease resistant andglobular in shape, while the carboxy-terminal region is proteasesensitive. The latter contains multiple phosphorylation sites forprotein kinase C, the binding site for calmodulin, and is requiredfor association with spectrin and actin. Alternatively splicedadducin gamma transcripts encoding different isoforms have beendescribed. The functions of the different isoforms are not known. |
| Further Information: | This ADD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 552-580 amino acids from the C-terminal region of human ADD3. |
| Synonym: | Gamma-adducin, Adducin-like protein 70, ADD3, ADDL |
| Ascension Number: | Q9UEY8 |
| NCBI EntrezGene: | 120 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
