| Applications: | IHC-P, WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit IgG |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | Accumulation of neurotoxic amyloid-beta is a majorhallmark of Alzheimer disease (AD; MIM 104300). Formation ofamyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM104311), a protease with numerous substrates. PION, or GSAP,selectively increases amyloid-beta production through a mechanisminvolving its interaction with both gamma-secretase and itssubstrate, the amyloid-beta precursor protein (APP; MIM 104760)C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed20811458]). |
| Further Information: | This PION antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 537-565 amino acids from the C-terminal region of human PION. |
| Synonym: | Gamma-secretase-activating protein, GSAP, Protein pigeon homolog, Gamma-secretase-activating protein 16 kDa C-terminal form, GSAP-16K, GSAP, PION |
| Ascension Number: | A4D1B5 |
| NCBI EntrezGene: | 54103 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
