| Applications: | FC, IF, IHC-P, WB |
| Species Reactivity: | Human |
| Isotype: | Rabbit IgG |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | Members of arrestin/beta-arrestin protein family arethought to participate in agonist-mediated desensitization ofG-protein-coupled receptors and cause specific dampening ofcellular responses to stimuli such as hormones, neurotransmitters,or sensory signals. Arrestin beta 1 is a cytosolic protein andacts as a cofactor in the beta-adrenergic receptor kinase (BARK)mediated desensitization of beta-adrenergic receptors. Besides thecentral nervous system, it is expressed at high levels inperipheral blood leukocytes, and thus the BARK/beta-arrestin systemis believed to play a major role in regulating receptor-mediatedimmune functions. Alternatively spliced transcripts encodingdifferent isoforms of arrestin beta 1 have been described, however,their exact functions are not known. |
| Further Information: | This ARRB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-363 amino acids from the C-terminal region of human ARRB1. |
| Synonym: | Beta-arrestin-1, Arrestin beta-1, ARRB1, ARR1 |
| Ascension Number: | P49407 |
| NCBI EntrezGene: | 408 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
