| Applications: | IF, IHC-P, FC, WB |
| Species Reactivity: | Human, Mouse |
| Isotype: | Rabbit IgG |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene encodes a transcription factor that containsfour zinc-finger motifs at the C-terminus and aproline/glutamine-rich DNA-binding domain at the N-terminus. It hasan essential role in the normal development of the urogenitalsystem, and it is mutated in a small subset of patients with Wilm'stumors. This gene exhibits complex tissue-specific and polymorphicimprinting pattern, with biallelic, and monoallelic expression fromthe maternal and paternal alleles in different tissues. Multipletranscript variants have been described. In several variants, thereis evidence for the use of a non-AUG (CUG) translation initiationsite upstream of and in-frame with the first AUG. Authors ofPMID:7926762 also provide evidence that WT1 mRNA undergoes RNAediting in human and rat, and that this process istissue-restricted and developmentally regulated. [provided byRefSeq]. |
| Further Information: | This WT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-375 amino acids from the Central region of human WT1. |
| Synonym: | Wilms tumor protein, WT33, WT1 |
| Ascension Number: | P19544 |
| NCBI EntrezGene: | 7490 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
