| Applications: | FC, IF, WB, IHC-P |
| Species Reactivity: | Human |
| Isotype: | Rabbit Ig |
| Purification: | Purified Rabbit Polyclonal Antibody |
| Description: | This gene belongs to the TIMP gene family. The proteinsencoded by this gene family are natural inhibitors of the matrixmetalloproteinases (MMPs), a group of peptidases involved indegradation of the extracellular matrix. In addition to itsinhibitory role against most of the known MMPs, the encoded proteinis able to promote cell proliferation in a wide range of celltypes, and may also have an anti-apoptotic function. Transcriptionof this gene is highly inducible in response to many cytokines andhormones. In addition, the expression from some but not allinactive X chromosomes suggests that this gene inactivation ispolymorphic in human females. This gene is located within intron 6of the synapsin I gene and is transcribed in the oppositedirection. |
| Further Information: | This TIMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-188 amino acids from the C-terminal region of human TIMP1. |
| Synonym: | Metalloproteinase inhibitor 1, Erythroid-potentiating activity, EPA, Fibroblast collagenase inhibitor, Collagenase inhibitor, Tissue inhibitor of metalloproteinases 1, TIMP-1, TIMP1, CLGI, TIMP |
| Ascension Number: | P01033 |
| NCBI EntrezGene: | 7076 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
