| Applications: | WB, IHC-P, FC, IF |
| Species Reactivity: | Mouse |
| Isotype: | Rabbit Ig |
| Purification: | Affinity Purified Rabbit Polyclonal Antibody |
| Description: | This gene is similar to the Drosophila additional sexcombs gene, which encodes a chromatin-binding protein required fornormal determination of segment identity in the developing embryo.The protein is a member of the Polycomb group of proteins, whichare necessary for the maintenance of stable repression of homeoticand other loci. The protein is thought to disrupt chromatin inlocalized areas, enhancing transcription of certain genes whilerepressing the transcription of other genes. The protein encoded bythis gene functions as a ligand-dependent co-activator for retinoicacid receptor in cooperation with nuclear receptor coactivator 1.Mutations in this gene are associated with myelodysplasticsyndromes and chronic myelomonocytic leukemia. Alternative splicingresults in multiple transcript variants. |
| Further Information: | This ASXL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the Central region of human ASXL1. |
| Synonym: | Putative Polycomb group protein ASXL1, Additional sex combs-like protein 1, ASXL1, KIAA0978 |
| Ascension Number: | Q8IXJ9 |
| NCBI EntrezGene: | 171023 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
