| Applications: | WB, IF, IHC-P |
| Species Reactivity: | Human |
| Isotype: | IgG1,K |
| Purification: | Mouse Monoclonal Antibody |
| Description: | This gene encodes a member of the transforming growthfactor beta (TGFB) family of cytokines, which are multifunctionalpeptides that regulate proliferation, differentiation, adhesion,migration, and other functions in many cell types by transducingtheir signal through combinations of transmembrane type I and typeII receptors (TGFBR1 and TGFBR2) and their downstream effectors,the SMAD proteins. Disruption of the TGFB/SMAD pathway has beenimplicated in a variety of human cancers. The encoded protein issecreted and has suppressive effects of interleukin-2 dependentT-cell growth. Translocation t(1;7)(q41;p21) between this gene andHDAC9 is associated with Peters' anomaly, a congenital defect ofthe anterior chamber of the eye. The knockout mice lacking thisgene show perinatal mortality and a wide range of developmental,including cardiac, defects. Alternatively spliced transcriptvariants encoding different isoforms have been identified. |
| Further Information: | This TGFB2 monoclonal antibody is generated from mouse immunized with TGFB2 recombinant protein. |
| Synonym: | Transforming growth factor beta-2, TGF-beta-2, BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, G-TSF, Polyergin, Latency-associated peptide, LAP, TGFB2 |
| Ascension Number: | P61812 |
| NCBI EntrezGene: | 7042 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
