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Cat Number:AP7101b-ev
Size:80uL
Price:£117.00
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Shipping:£12.00

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Data Sheet
MSDS

 

Activin Receptor Type IA [ACVR1] [N-term] [RB06512], Rabbit Polyclonal Antibody

Partner: Abcepta, Inc.

Applications:WB, IHC-P
Species Reactivity:Human, Rat
Isotype:Rabbit Ig
Purification:Purified Rabbit Polyclonal Antibody
Description:Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is an activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.
Further Information:This Activin Receptor Type IA (ACVR1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human Activin Receptor Type IA (ACVR1).
Synonym:Activin receptor type-1, Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, ACVR1, ACVRLK2
Ascension Number:Q04771
NCBI EntrezGene:90
Shipping Conditions:Ship on cold packs
Storage:Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles.
Usage:Research use only

 

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Western blot analysis of lysates from A549,HepG2 cell line and rat testis tissue (from left to right),using ACVR1 Antibody (N-term)(Cat. #AP7101b).AP7101b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.

Western blot analysis of lysates from A549,HepG2 cell line and rat testis tissue (from left to right),using ACVR1 Antibody (N-term)(Cat. #AP7101b).AP7101b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.